62
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12580 |
PTUPB
|
COX; Epoxide Hydrolase | Immunology/Inflammation; Metabolism; Neuroscience |
PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。 | |||
T2601 |
Vidofludimus
SC12267,4sc-101 |
Dehydrogenase; DNA/RNA Synthesis; Interleukin | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Vidofludimus (SC12267) 是一种新型的二氢乳清酸脱氢酶 (DHODH) 小分子抑制剂,可在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。 | |||
T0456 |
Cinchophen
2-苯基-4-喹啉羧酸,辛可芬,Cinconal |
COX | Immunology/Inflammation; Neuroscience |
Cinchophen (Cinconal) 是口服具有活性的非甾体抗炎试剂,具有抗菌活性。它可用于研究关节炎和某些肝脏疾病。 | |||
T2171 |
SEW2871
SEW2871 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
SEW 2871 是一种可口服的高选择性 S1P1激动剂,EC50为 13.8 nM。它减少血液中的淋巴细胞数量,可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路,并诱导 S1P1 内在化和再循环。 | |||
T3053 |
CZC-25146
CHEMBL2397014 |
LRRK2 | Autophagy |
CZC-25146 (CHEMBL2397014) 是一种有效、特异性和代谢稳定的 LRRK2 抑制剂,对野生型 LRRK2 和 G2019S LRRK2 的 IC50 分别为 4.76 和 6.87 nM。 | |||
T5139 |
CZC-25146 hydrochloride
|
LRRK2 | Autophagy |
CZC-25146 hydrochloride 是一种有效、特异性和代谢稳定的 LRRK2 抑制剂,对野生型 LRRK2 和 G2019S LRRK2 的 IC50 分别为 4.76 和 6.87 nM。 | |||
T1090 |
Perphenazine
Perphenazin,Etaperazine,Trilafon,奋乃静 |
CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂,具有止吐和抗精神病特性。它能够抑制5-HT2A 受体,α1A 肾上腺素能受体,多巴胺D2、D3、D2L 受体,以及组胺H1受体,对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。 | |||
T9010 |
IMM-H007
|
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
IMM-H007 是一种新型降脂剂,可增加 abca1 蛋白的表达。 | |||
T1406 |
Amantadine hydrochloride
盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride |
Dopamine Receptor; Influenza Virus | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Amantadine hydrochloride (CI-719) 是一种抗病毒药物,用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。 | |||
T37184 |
CX08005
2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid |
Phosphatase | Metabolism |
CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂,可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。 | |||
T38715 |
MSDC-0602K
MSDC-0602K,Azemiglitazone potassium |
PPAR | DNA Damage/DNA Repair; Metabolism |
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ... | |||
T0080 |
Trapidil
唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008 |
PDGFR; PDE | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Trapidil (Avantrin) 是一种抗血小板药物,是一种血管扩张剂,有特异性血小板衍生生长因子。 | |||
TQ0223 |
Lusutrombopag
芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta |
Thrombin; Thrombopoietin Receptor | Immunology/Inflammation; Proteases/Proteasome |
Lusutrombopag (Mulpleta) 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂,用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。 | |||
T61389 |
TGFβ1-IN-1
|
||
TGFβ1-IN-1(化合物42)是一种有效且可口服的TGF-β1抑制剂,能够抑制TGF-β1诱导的纤维化标志物(α-SMA和纤连蛋白)的上调,适用于肝纤维化疾病的研究。 | |||
T63016 |
Nrf2 activator-4
|
Reactive Oxygen Species; Nrf2 | Immunology/Inflammation; Metabolism; NF-κB |
Nrf2 activator-4 是一种具有口服活性的 Nrf2 激活剂(EC50: 0.63 μM),对小神经胶质细胞中活性氧的产生有抑制作用,用于治疗人类代谢功能障碍相关的脂肪肝病。 | |||
T50000 |
2-Iodohippuric Acid
|
Others | Others |
2-Iodohippuric Acid 可以用来测量肾脏的清除率用于肾功能研究,也用于某些疾病的诊断,如肝病和肾病。此外,它还用于某些药物的合成。 | |||
T6647 |
Rotigotine-
Neupro,N-0923,罗替戈汀,N-0437,SPM 962 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Rotigotine (N-0923) 是多巴胺受体激动剂,是5-HT1A receptor 的部分激动剂,以及α2B-肾上腺素受体的拮抗剂,用于治疗帕金森病和不宁腿综合征。 | |||
T0192 |
Levetiracetam
左乙拉西坦,UCB L059,SIB-S1 |
DNA Methyltransferase; Others; Calcium Channel | Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; Others |
Levetiracetam (SIB-S1) 是一种化学增敏剂,增强 Temozolomide 对胶质母细胞瘤干细胞增殖和凋亡的影响。它调节 HDAC 水平,最终使 MGMT 沉默从而提高 Temozolomide 的有效性。它是一种抗癫痫药,可结合突触小泡蛋白 SV2A。 | |||
T0083 |
Eplerenone
Epoxymexrenone,CGP 30083,依普利酮,SC-66110 |
Glucocorticoid Receptor | Endocrinology/Hormones |
Eplerenone (CGP 30083) 是一种竞争性的、选择性的、具有口服活性的醛固酮 (aldosterone) 拮抗剂,IC50=138 nM。它对孕酮,雄激素,雌激素和糖皮质激素受体的亲和力低,可用于研究高血压和心肌梗死后的心力衰竭。 | |||
T1476 |
Pramipexole
SND 919,普拉克索 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pramipexole (SND 919) 是能够透过血脑屏障的 D2 型多巴胺受体的选择性激动剂,对 D2 型受体、D2、D3、D4亚型受体的Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。它可用于研究帕金森综合症和腿多动综合征。 | |||
T34107 |
Polythiazide
P2525,NSC-108161,NSC 108161,P-2525,NSC108161 |
||
Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication. | |||
T40302 |
FXR/TGR5 agonist 1
|
||
FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease. | |||
T11448 | GOAT-IN-1 | Others | Others |
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral infa | |||
T61599 | XT2 | ||
XT2 is a highly potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK), exhibiting an IC50 of 9.1 nM. It effectively suppresses the upregulation of ALT, a vital biomarker for acute liver injury, induced by CCl4. Additionally, XT2 significantly decreases immune cell infiltration into the damaged liver tissue. As a result, XT2 holds immense potential in liver inflammatory disease research [1]. | |||
T78093 |
Cisd2 agonist 1
|
Others | Others |
Cisd2 agonist 1 (Compound 4q)为一种EC50值为34 nM的Cisd2激动剂,可增强Cisd2表达并改善非酒精性脂肪肝疾病(NAFLD)的病理改变,同时具备良好的代谢稳定性,适用于NAFLD研究。 | |||
T63818 |
Omesdafexor
|
||
Omesdafexor 是 FXR 激动剂,能够用于研究肝病或代谢性炎症引起的疾病。 | |||
T74132 |
GLP-1 receptor agonist 8
|
||
GLP-1 receptoragonist 8 是一种有效的GLP-1R 激动剂。GLP-1 receptoragonist 8 具有研究糖尿病、肥胖和非酒精性脂肪肝 (NAFLD) 的潜力。 | |||
T73777 |
Coproporphyrin I
|
||
Coproporphyrin I 是存在于血液和尿中的内源代谢物,可用于研究肝病和卟啉症。 | |||
T35801 |
ML-262
|
||
ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit fatty acid uptake (up to 50 μM). | |||
T38281 |
C22 Galactosylceramide (d18:1/22:0)
|
||
C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2[Matreya, LLC.] | |||
T83421 |
1-Palmitoyl-sn-glycerol 3-phosphate
1-P-GPA |
||
1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) 是内源性代谢物,常用于非酒精性脂肪性肝病的研究。 | |||
T21978 |
p-nitro-Pifithrin-α
|
||
p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4]. | |||
T62029 |
ML261
|
||
ML261 是肝脂滴形成的抑制剂,IC50值为 69.7 nM。ML261 在非酒精性脂肪性肝病 (NAFLD) 和炎症中具有研究价值。 | |||
T78313 |
Fazpilodemab
BFKB8488A |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Fazpilodemab (BFKB8488A) 是靶向 FGFR1c 和 Klothoβ 的激动性人源化双特异性抗体,适用于T2DM或NAFLD的研究。 | |||
T73231 | RR-RJW100 | ||
RR-RJW100是RJW100的对映异构体之一,后者为核受体肝受体同源物1(LRH-1)和类固醇生成因子1(SF-1)的激动剂。相比于另一对映异构体SS-RJW100,RR-RJW100展现出更强的LRH-1激活能力。此化合物在调节代谢稳态方面具有潜力,因而在糖尿病、肝病以及炎症性肠病等疾病的研究中有所应用。 | |||
T75150 | GIP/GLP-1 dual receptor agonist-1 | ||
GIP/GLP-1 dual receptor agonist-1 (化合物 4) 是一种 GIP/GLP-1双受体激动剂。GIP/GLP-1 dual receptor agonist-1 可用于代谢紊乱和脂肪肝病,包括非酒精性脂肪性肝炎 (NASH)、非酒精性脂肪性肝病 (NAFLD) 的研究。 | |||
T71560 | Atorvastatin magnesium trihydrate | ||
Atorvastatin magnesium trihydrate is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia. | |||
T71492 |
Atorvastatin strontium
|
||
Atorvastatin strontium is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.Atorvastatin is also used for the treatment of dyslipidemia. | |||
T35443 |
1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
|
||
1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral loss MS. Increased serum levels of 1-palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol are a potential biomarker for non-alcoholic fatty liver disease (NAFLD). | |||
T72997 |
HIF-2α-IN-7
|
||
HIF-2α-IN-7 是一种缺氧诱导因子 2α(HIF-2α)抑制剂。HIF-2α-IN-7 抑制 HIF-2α,EC50值为 6 nM。HIF-2α-IN-7 可用于多种疾病的研究,包括癌症、肝病、炎性疾病、肺病和铁负荷紊乱。 | |||
T62589 |
TRPC5-IN-4
|
||
TRPC5-IN-4 是一种有效且安全的TRPC 抑制剂,对TRPC5和TRPC4的IC50分别为 14.07 nM 和 65 nM。TRPC5-IN-4 对肝、肾细胞成分无损伤。TRPC5-IN-4 可用于慢性肾脏病的研究 (CKD)。 | |||
T62277 |
PPARδ agonist 8
|
||
Pparδ agonist 8 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族,在体内代谢稳态、炎症、细胞生长和分化的调节中具有关键作用。Pparδ agonist 8 具有潜力进行非酒精性脂肪肝 (NAFLD) 的研究。 | |||
T35809 |
C20 Sphingomyelin (d18:1/20:0)
|
||
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m... | |||
T70899 |
Vidofludimus hemicalcium
4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium |
||
Vidofludimus (4sc-101 ; SC12267) hemicalcium 是一种口服有效的二氢乳清酸脱氢酶 (DHODH) 的抑制剂,也是法尼醇 X 受体 (FXR) 调节剂。Vidofludimus hemicalcium 作为一种免疫调节剂,可用于研究自身免疫性疾病,如炎症性肠病 (IBD)。Vidofludimus hemicalcium 还可通过靶向FXR 用于脂肪肝的研究。 | |||
T75089 | Selachyl alcohol | ||
Selachyl alcohol是一种具有口服活性的降压剂,与抗高血压中性重髓质脂(ANRL)活性相似。这种烷基甘油化合物存在于鲨鱼鱼肝油混合物中,具有减少肺转移特性,可用于心血管疾病研究。 | |||
T37439 |
C18 Globotriaosylceramide (d18:1/18:0)
|
||
C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma... | |||
T72889 | FXR agonist 4 | ||
FXR agonist4,一种法尼酯X受体(FXR)激动剂,具有1.05 μM的EC50值。该化合物在DIO小鼠模型中有效地改善了高脂血症、肝脏脂肪变性、胰岛素抵抗以及肝脏炎症,因此可用于非酒精性脂肪性肝病(NAFLD)的研究。 | |||
T79321 |
nSMase2-IN-1
|
Phospholipase | Metabolism |
nSMase2-IN-1是一款口服活性的nSMase2抑制剂,具有0.13 ± 0.06 μM的IC50。该化合物在肝脏微粒体内具有良好的代谢稳定性,口服给药后获得较高的脑血浆比值,适用于神经系统疾病研究。 | |||
T63975 |
MAT2A-IN-1
|
||
MAT2A-IN-1 是 MAT2A 的有效抑制剂,能够 MTAP 缺陷型癌细胞的增殖活性。其中 MAT2A 在几种类型肿瘤中表达水平异常高,包括胃癌、结肠癌、肝癌和胰腺癌。MAT2A-IN-1 对癌症疾病表现出研究潜力。 | |||
T78095 |
Demethyleneberberine chloride
|
NF-κB | NF-κB |
Demethyleneberberine chloride是一种具有线粒体靶向性的天然抗氧化剂,能通过抑制NF-κB通路及调节Th细胞平衡来缓解小鼠结肠炎并抑制炎症。此外,作为一种AMPK激活剂,该化合物亦用于非酒精性脂肪性肝病(NAFLD)的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1923 |
Schisandrin C
五味子丙素,Schizandrin-C,Wuweizisu-C |
Apoptosis; Others; Virus Protease | Apoptosis; Microbiology/Virology; Others |
Schisandrin C (Wuweizisu-C) 是从五味子中分离得到的一种植物化学木脂素。它具有抗癌、抗炎和抗氧化等多种生物活性,可研究癌症、阿尔茨海默病、肝病。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
T0461L |
Berberine sulfate
AI3-61947,Berberin sulfate,Berberine sulphate,Berberal |
||
Berberine sulfate (Berberal) 是苄基异喹啉生物碱原小檗碱类的季铵盐,可用于研究2型糖尿病、腹部肥胖和代谢相关脂肪性肝病。 | |||
T21977 |
p-Cresyl sulfate
|
Others | Others |
p-Cresyl Sulfate 是主要的尿毒症毒素,存在于慢性肾病患者的血液,来源于肝脏中酪氨酸和苯丙氨酸的代谢物。 | |||
T3804 |
Neomangiferin
Mangiferin 7-glucoside,新芒果苷 |
Phosphatase | Metabolism |
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。 | |||
T6752 |
S-Adenosyl-L-methionine disulfate tosylate
S-腺苷蛋氨酸对甲苯磺酸硫酸盐,Ademetionine disulfate tosylate |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) 是一种主要生物甲基供体,在所有哺乳动物细胞中合成,但在肝脏中含量较高。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。 | |||
T5S0754 |
Isoquercetin
3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷 |
NF-κB; Wnt/beta-catenin; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells |
Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚,具有抗氧化,抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性,氧化应激和炎症反应。它具有高生物利用度和低毒性,是预防糖尿病妊娠出生缺陷的有希望的候选药物。 | |||
T3S0013 |
Ethyl trans-caffeate
咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester |
Others | Others |
Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。 它是一种有前途的天然化合物,未来在慢性肝病中的应用。它是一种有效的化学预防化合物,可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。 它强烈抑制 JB6 Cl41细胞的肿瘤转化,无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。 | |||
T4938 |
Potassium 1H-indol-3-yl sulfate
硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate |
AhR; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。 | |||
T7732 |
Carbenoxolone
Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral |
Dehydrogenase; Gap Junction Protein | Cytoskeletal Signaling; Metabolism |
Carbenoxolone (Carbenoxolona) 是 11β-HSD 和 gap junction connexin 通道的抑制剂。 Carbenoxolone 抑制巨噬细胞迁移到心房并防止脂肪肝的发展。 | |||
T37291 |
Lyso-Globotriaosylceramide (d18:1)
Lyso-Globotriaosylceramide (d18:1) |
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Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas... | |||
TN5431 |
Icariside E4
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Antioxidant; AMPK; Liver X Receptor; Lipid; Fatty Acid Synthase | Chromatin/Epigenetic; Metabolism; oxidation-reduction; PI3K/Akt/mTOR signaling |
Icariside E4是一种从小叶榆中提取得到天然化合物, 通过AMPK 磷酸化和抑制HepG1细胞中MID1IP2的低脂化作用。Icariside E4具有抗伤害,抗氧化,抗阿尔茨海默氏症和抗炎作用,抑制了SREBP-1c,肝脏X 受体-α(LXR)和FASN 在HepG2细胞中从头脂肪生成的表达。Icariside E4是治疗脂肪肝疾病的有效候选药物,在HepG1细胞中具有低脂化潜力。 | |||
T35624 | Ajoene | ||
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |